Logan's primary research is focused on understanding how genetic variations in our DNA cause an increased risk of cancer for some individuals.
Identification of cancer-causing mutations in the breast cancer susceptibility genes, BRCA1 and BRCA2, has well-defined and actionable implications for disease prevention. However, routine diagnostic BRCA1 and BRCA2 gene screening is expensive and up to 90 per cent of these genetic tests do not return a positive result suggesting that the current selection criteria for genetic testing are inefficient. Furthermore, about 15 per cent of these tests identify a DNA sequence variant that is of unknown clinical significance creating a significant challenge for counselling and clinical decision making.
Logan is leading the team at the University of Otago that will aim to exploit a powerful new mRNA in situ hybridisation technology to develop an innovative method for prioritising patients for mutation screening and evaluating genomic sequencing results. This study has the potential to identify tumours from both familial and sporadic forms of breast cancer that may respond to drugs targeting altered BRCA1/2 genes and related pathways.